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happiness

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happiness last won the day on December 13 2018

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  1. The academic medical and biosciences community seems to overwhelmingly support the FDA system. The two groups—academics and bureaucrats—seem to have a very symbiotic relationship. What is it?
  2. I recall a part of Atlas Shrugged where Hank presses Dagny to tell him who her previous lover was. Why would he care if he was a strong, confident man?
  3. She actually isn't promiscuous; she said she had been celibate for over a year. She rejected me because I turned out to be the opposite of what she expected. She took my initial rejections as a sign of strength, and I turned out to be timid, needy, supplicating nice guy and have no idea how to handle myself with a woman.
  4. Having put a lot of thought into this issue over the last six months, I decided that I could never be “just friends” with this woman. Even though we aren’t a match romantically, I am only able to think of her in light of my attraction to her, and sex is always my end game. I would feel not only dishonest, but degraded being in a relationship with her in which there is one-way attraction which we are both aware of. When I was dating her, she was receiving attention from several other men at work, all of whom she rejected, but remained friendly with. I felt such pity for them; orbiting her, giving her attention which she didn't return (she wasn’t exploitive in any way to my knowledge). I’m very embarrassed that I temporarily acted like them while hanging on for dear life. Maybe I would feel differently in the case of another woman, but I’m positive I have no interest in a platonic friendship with this one. And despite what came out of her mouth, I know she didn’t really want one with me, either. While she was genuinely friendly with the other men she rejected, after calling it quits with me, she saw me as the guy she chased that it didn't work out with, not a friend.
  5. I only want blunt replies. For the record, I'm very keenly aware of everything I did wrong with her, I just hadn't dated in so long before this I had to learn these lessons the hard way.
  6. Well... Jaskn was right. I’ll take responsibility for the other stupid thread overlapping with this story and reiterate the details: January 2018 I started a new job, where a very attractive female member of the training staff took a liking to me and became flirtatious immediately. I did not reciprocate her advances, which in turn escalated to the point of being overtly sexual. Every time she would say something, I would just ignore her and act like it didn’t happen. In private I was always very superficially attracted to her, but kept it to myself because she was a co worker and I knew we weren’t a good match. She was very good at her job and we had a fantastic working relationship. This pattern of her flirting and me ignoring it continued for 4-5 months until one night in late May she when she added me on FB and came on to me hard. She said the fact that I ignored her drove her crazy and made her desperate for my attention, and basically begged me to date/sleep with her. I initially turned her down, the red flag there being pretty obvious, but she kept working on me for two weeks until I finally changed my mind and agreed to go out with her. We dated casually for five weeks. We had some fun, but as I thought, didn’t mesh well in a romantic level. Our relationship revolves around work, and outside of that there was always a lot of friction between us. I don’t know why, but I still caught painfully strong feelings for her, which I kept to myself because I knew she was the less interested party. I made a ton of mistakes in dealing with her, including spending way too much damn time with her. There was nothing I wouldn’t blow off to be with her, and she must have picked up on it. At five weeks, like a switch flipped, she shut me down overnight. She stopped texting first, became aloof at work, stop inviting me to hang out after. She never said we were done, but sent a stream of nasty signals; things like referring to us as “friends” and complaining to her girlfriends within earshot of me that she would be single for life. She would only socialize with me in a group setting, never alone. Like a chump, I stuck around and orbited her as a “friend,”pretending to accept a platonic relationship when I should have gotten the Hell away from her. I wasn’t ready to accept that it was over even though I knew it was. A few weeks after shutting me down, she shared in our group text that she had plans to hook up with someone else that night. A few weeks prior, she had made plans to spend that weekend with me; so she blew me off, replaced me in her sex plans and texted it where she knew I would read it. I was absolutely shattered. Months later, I found out the guy she hooked up with was Johnny, another co-worker and close friend of hers whom I had believed was thoroughly friend-zoned and never considered a threat. I knew she was fond of him on a friendly level, but never thought in a million years that she’d be attracted to him. He always whined to her about his problems, which didn’t impress her. I finally quit the friendship act and cut contact. I also quit my job. I only saw her once more after that, when I stupidly agreed to accompany her to the hospital to visit a mutual friend, and it was a very uncomfortable encounter. We fell out via text the following day and that was the end of the relationship, five months ago. Her rejection cut deep, and I was pretty screwed up for the first few months after, sat around pining and plotting ways to get back with her. At this point, I’m not carrying a torch for her anymore and have accepted that there’s no coming back from this. Our relationship is dead and buried and I will never, and should never see or hear from her again… unless I go back where she is. I got a new job, but it’s much further away, and offers fewer hours, so I’m losing a lot of money by avoiding her. I’m a few months away from being ready, but it would be in my best interest to go back to my old job, if not not for her presence there. How bad of an idea is it to go back? If I do so, what should be my strategy for dealing with her be? This woman ripped my heart out of my chest and stomped on it. I wish we could go back to our old working relationship before things got real, but I feel like that's impossible. I am NOT comfortable working directly with her again and do NOT want platonic contact with her, period. I hear she’s now in recruiting, which means she could be involved in processing my application. I don’t know what interaction I’d have with her beyond that. My options, as I see them: Don’t go back Go back, but put up a wall and refuse to deal with her period. Tell her straight up not to talk to me, disclose everything to management, and ask them to keep us separated. Deal with her in a strictly professional manner, but tell her we can only talk if it’s work related. Let her talk to me if she wants, but be an aloof acquaintance and never initiate conversation or give her attention. Just treat her like every other co worker I don’t give a damn about.
  7. I’m in the Cayman Islands now, where I just had my second Regenexx-C procedure with culture-expanded stem cells. I saved for it for two years. We treated almost every joint in my body. The first procedure 20 months ago probably saved my life, and I’m stoked to get even more improvement from this one.
  8. I picked up this summary of "TRP" philosophy from reddit. I don't see much of anything that I disagree with. ________________________________ Unplugging from the Feminine Matrix can be nearly as painful as Neo emerging into a very different reality. It is often a very painful process to review your past relationship failures and develop an entirely new understanding of them. Many guys kick themselves over and over again, lamenting the lost years when they were trapped by a society stacked against them and a set of beliefs and ideologies that simply do not work. They were told to "Just Be Yourself." They stayed "Friend" with girls who rejected them in hopes of earning their favor. They married women for richer or poorer who divorced them when the business dried up and seemingly changed overnight. Men have various problems with unplugging but perhaps the greatest is the discovery that women don’t want to hear about your problems, your deep emotions, and that they don’t love you in the way society and Disney has promised you will be loved. There is no Fairy Tale and there is no such thing as unconditional love. Women want a strong, masculine, rock to lean on during their monthly emotional roller coaster. All we have been told about “communication” and “sensitivity” and being a good “provider” being the keys to making a woman want to have sex with you WAS A LIE. Yes, it was all a Shit Test and you fell for it...which helps explain why there is often so much anger when unplugging. Let us, just for a marked change of pace try for a moment to consider the man’s perspective. Consider the typical divorce filed in 80% of cases by the woman for no reason except she is somehow unaaapppy. She goes to find her happiness, he loses his wife, children, ½ of his income plus child support and still only sees his kid once a month. His wife divorced him to fuck Hawt Alpha-Fuck who now sleeps in his bedroom, on his bed, and wakes up his kids with her screams while he rails her. That is not an exception or unusual in any way. That is very, very common. When you realize there were ways that you could have acted and beliefs you could have adopted that would have retained the attraction, or generated the attraction in so many other cases, the only possible response is anger. In fact, unplugging goes through all the stages of grief because you are, in effect, giving up and mourning an entire set of beliefs- Denial, Anger, Bargaining, Depression, Acceptance. The Tingles: The vaginal tingles are more than getting her wet. A women who gets the tingles is wet and wants to get fucked, usually hard. Alpha behaviors generate the tingles. Beta Behaviors may be nice and sweet but they do not generate the tingles. Omega behaviors turn off the tingles. Male/Female Attraction Cues: Basically, whatever is good for making (and raising!!) babies is what the other sex finds sexually attractive. Men: Young hourglass figured fertile female with big boobies. Women: Strong leader able to protect and provide for the children. Check out The Rational Male for many exceptional articles on this topic. Alpha: There is not total agreement on this nebulous concept. The “Alpha Male” is the guy who always has girls hanging off him and probably will rack up a triple digit “n” count (of sexual partners) while creating many Alpha Widows ready to divorce her Beta husband for cash and prizes after she fakes it with him for a few years. The Alpha is in the “top” 10% or so of attraction quotient. He is comfortable around women, handsome, masculine, confident, self- assured, and often arrogant and narcissistic. He is usually dismissive of women and treats them like a kid sister, completely unfazed by her charms. This is enormously sexually attractive to women and the foundation of “Game” which is an attempt to mimic the Alpha behaviors of men who are successful with women. Beta: The poor provider who gets shit on by everybody and rarely gets laid characterizes the Beta. A Beta male shows his sensitive side to women. He does not stand up to them but instead bows down to the divine majesty of feminine power. The Beta Husband’s motto is: “I have to do whatever she says because she has the pussy.” A Beta does not recognize or stand up to Shit Tests. Beta has a bad reputation because while it is behavior that makes women feel warm and fuzzy inside, it does not activate the tingles or make her horny. SOME Beta behaviors are necessary for any LTR but the vast majority of men today have been conditioned to overdo it by orders of magnitude. Omega: The real worthless dregs of sexual society are the Omega’s. These guys don’t just worship pussy, they put it on a pedestal, they stand in awe of it often to the point they can’t even approach a girl without shivering in fear. They live lives of desperation until ultimately they are “chosen” by a land whale who mines him for the meager resources he is able to provide. Omega behaviors don’t provide vaginal tingles and they don’t make anybody feel good. The most common adjectives for them are “pathetic”, “ridiculous”, and “cringe-worthy.” Hypergamy: “Marrying Up” is a very strong instinct in women. Women want a man who is taller, smarter, wealthier, and a better conversationalist who leads them in the bedroom and out. They get sexually aroused when a man takes charge and leads. Conversely, this means women do NOT become sexually aroused unless the man is fulfilling her hypergamous instinct. If his father dies, or he becomes depressed, the woman's hypergamous instinct will quickly surface and she will lose sexual attraction. In today’s feminine matrix, Hypergamy means that 10% of the men have 90% of the sex while the vast majority of men are starved for affection and female attention. Hypergamy means if you are married your wife is ALWAYS looking to trade up and, she will always be like a monkey, ready to swing to the next branch while her other hand is still firmly on the previous branch. Men are also hypergamous and prefer younger, more fertile, and curvy women. However, the dual mating strategy of women makes hypergamy especially problematic because it is virtually impossible to satisfy! If you are Albert Alpha with a 10 inch cock who fulfills all her darkest dreams, she will begin to yearn for Billy Beta who listen to her feeewings and whisper sweet nothings into her ear. Hypergamy means simply that women are never satisfied and can never be satisfied. Their levels of dissatisfaction can only be managed, never satisfied, says hypergamy. Female Dual Mating Strategy: AF/BB- Almost all women want Alpha Fucks. They get wet when a powerful, masculine male asserts dominance and leads them into passionate sex which they think “just happened.” In fact, a strong man led them to it but don’t tell them that- magicians and their tricks and all. Almost all women ALSO want Beta Bucks. They want a provider to take care of them and are more than willing to fake passion and give up sex for years in order to get it. Shit Tests: Women test men to determine if they are really a “leader” worthy of an Alpha Fuck. Most of the time it is unconscious and they have no idea what they are doing. A Shit Test is an unreasonable tone or attitude. A Shit test in Pick Up situations is the standard bar-banter with the peacocking, feather strutting, pretend Alpha males withstanding the verbal barrages from the interested females. The solution in BOTH situations is Agree and Amplify, ignore, deflect, amused mastery (treat it like it is something an endearing little girl did) or nuke (call them out and stop it). Game: A set of behavioral modifications consistent with observations implemented in order to maximize attraction. Game is being the “Alpha” male, cocky, funny, arrogant, irrationally confident, easy going, in charge, strong, masculine. Game has been criticized as inauthentic and praised as equivalent to makeup and heels. Early game was sometimes reduced to memorized scripts but more recent game emphasizes the devil-may-care attitude of complete confidence, preferably with a smirk. The word is ‘fake it until you make it.’ Frame: Your reality is your “frame.” The unflappable, cool, calm, rational, Alpha dude who attracts women is a good frame. If a girl is irritated and rude this is a Shit Test and a test of your Frame. Responding to her in kind with rudeness, hostility or anger is ‘adopting her frame.’ Responding to her like she is a child and you are the adult is ‘maintaining your frame.’ Your "frame" is WHO you are at your best. The Hamster: The female rationalization hamster is widely known as the deadliest animal with the most endurance of any rodent in the universe. Actually the Hamster is another metaphor and a critique of female psychology, suggesting that women often use emotion to literally rewrite history in their own minds. Imagine a hamster running on a wheel going round and round and round, changing little emotional perceptions of something that happened and you get a small sense of the power of this beast. Let me give you an insight into the workings of the hamster with a real world example. A girl is laying in her bed thinking and the Hamster wheel powers up: I had sex with Tom yesterday. It was OK. Tom didn’t call back today. Tom didn’t respond to my text. Tom is an asshole. I would not have had sex with an asshole. Tom was pretty aggressive when he was fucking me. It wasn’t even that good. Tom didn’t get my verbal consent. Tom had sex with me and I didn’t consent. That asshole Tom raped me…squeak squeak!! Men also have a Hamster. The Cock Carousal: Like the horses on a carousal going up and down, a woman on the CC jumps from cock to cock as the wheel goes round. Our society encourages women to jump on as many Alpha cocks as she can find in her 20’s to satisfy the Alpha Fucks while she is then encouraged to “settle down” in her 30’s with the same type of man that she sneered at, ignored, and belittled in her 20's). As the Wall approaches the CC rider suddenly decides that she is no longer a slut. Now she is a born-again virgin and her new boyfriend, a niiice guy who makes good money is not going to get sex on the first date, or the 2nd or the 5th. Nope, she needs to establish this new relationship where she rations the sex in order to control her husband. She settles for a Beta Buck who can never excite her like all the hawwwt guys she could never get to commit. She throws sex at her Beta pet for months or years, as long as it takes, and then it tapers off, usually to twice a month, often beginning on the Honeymoon. The Wall: Beautiful women spend their youth not just fucking Alpha cocks and rewarding the most arrogant, aloof, “bad guys” they can find but also reaping all the benefits of their beauty and fertility. Men fall over themselves to please them. They have sexless male orbiters buy them things and provide validation when yet another hawwwt “Boyfriend” pumps and dumps them. They get let into the clubs. Men approach them and give them attention. Then, fate steps in and suddenly they are like a former star football player who is now beat up, used up, has 1 to many concussions, and suddenly the men (teams) are not paying them attention any longer. A woman whose eggs in the fridge are nearing their expiration date is slamming into the wall and their clock is ticking to lock down a provider to take care of them. See also “Baby Rabies.” Solopsism: As a consequence of their privileged position in society, and their natural biology, coddled women learn to think in terms of me…me…me. Women are wholly incapable of accepting the suffering of a man- if anything it is sexually arousing to them to see a man hold up under prolonged torture. However, if the man succumbs to the torture, she will feel nothing but disgust. See also Threatpoint or “Sexual Denial in Marriage 2.0.”
  9. A female co worker (who was formerly my trainer) five years my senior has been flirting with me on the job since day one. At first, I took it as joke and blew her off, but I’ve noticed she doesn't seem to do it with the other guys there, and lately she's been ramping it up...by doing stuff like rubbing my back, grabbing my leg, and slipping in a few overtly sexual comments. Though I feign disinterest, I secretly like it and am attracted to her even though I’m pretty sure she’s a different walk of life and not a long-term match for me. I’m aware of the adage “don’t shit where you eat,” but is it really that wise? Hank and Dagny were co-workers, right?
  10. Maybe this country still has a sliver of decency, but the people who oppose this don’t. The HillHouse passes 'right to try' drug billBY RACHEL ROUBEIN - 03/21/18 The House passed “right to try” legislation on experimental drugs largely along party lines Wednesday, sending a bill backed by President Trump to the Senate.Last week, House Republican leaders put the bill on the floor under suspension of the rules. Democrats objected, expressing safety concerns over how the measure would bypass the Food and Drug Administration, and it fell short of the necessary two-thirds support it needed.But leaders made clear the House would take up the bill again. On the second try, the House only needed a simple majority to pass the bill, and easily did so in the 267 to 149 vote.Thirty-five Democrats voted for the bill, and two Republicans opposed it. Now, the measure goes to the Senate, where a version of the bill passed in August by unanimous consent.Sen. Ron Johnson (R-Wis.), who has championed the bill in the Senate, urged his chamber to quickly pass the measure. “Right to try needs to become the law of the land. It passed the Senate unanimously last summer, and I’m disappointed the House didn’t pass that bill and send it to the president for his signature," Johnson said in a statement."Nonetheless, I plan to ask my colleagues to pass right to try again immediately. Terminally ill patients and their families have waited long enough.”House Republicans revised the bill amid objections from some supporters who had hoped the Senate version would pass, wanting to prevent the measure from ping-ponging between the two chambers. They worried that could make it harder to get the bill to Trump’s desk.The bill lets terminally ill patients request access to drugs the FDA hasn’t yet approved without going through the agency. Patients can request the drugs from manufacturers if the medicine has gone through a small-scale clinical trial and is still under FDA consideration.Though no senators objected to the bill, the legislation — which had been revised — proved controversial in the House.Democrats there, as well as more than 75 patient advocacy groups, have voiced several different concerns, and patient safety was chief among them.“By allowing patients access to investigational treatments that have only completed a phase 1 clinical trial, patients will be exposed to treatments with no or relatively little data that they are actually effective,” the top Democrat on the House Energy and Commerce Committee, Rep. Frank Pallone Jr. (N.J.), said during the debate on the House floor Wednesday.“These extremely small trials only examine the safety and toxicity of a drug and do not determine the effectiveness or potential side effects.”Opponents of the bill also point to the FDA’s compassionate use program, saying the agency approves 99 percent of requests to let a patient use an experimental drug. They argue the legislation provides “false hope,” as drug manufacturers aren’t required to provide the drug to patients who ask.But House Energy and Commerce Chairman Greg Walden (R-Ore.) and health subcommittee chairman Rep. Michael Burgess (R-Texas) maintained that their version of the bill struck “the right balance for patients and their safety.”Supporters of the measure have argued that people with a terminal illness should have every tool at their disposal to try a drug that could possibly help them.Rep. Morgan Griffith (R-Va.) said that if faced with a terminal illness, he’d “take any risk, including injecting monkey urine if that meant I could spend a few more days, months or years with my children.”Proponents of the legislation have also argued that the drug approval process takes too long, and that the bill isn't unsafe, as medicines must have passed a phase 1 clinical trial and still be in FDA’s pipeline.The legislation has powerful backers.President Trump has urged Congress to pass the bill, notably in his State of the Union address in late January. Vice President Pence is a staunch supporter of right to try, signing the bill into law when he was governor of Indiana. And groups backed by conservative mega-donors Charles and David Koch have also been pushing for its passage.
  11. Had a couple of super uncomfortable encounters today. While on a bike ride I ran into a guy who was a close friend for a very long time, but whom I haven’t seen or talked to much in the last five years. He’s a successful insurance agent now, which I respect, but has taken to getting involved in local politics (I believe) as a form of marketing, which I’m not so impressed with. He’s a leader in a local organization that campaigns for school bonds and posts a bunch boring stuff about it on FB. During our brief convo, he mentioned the school levy coming up and casually “reminded” me to support it. Not wanting to disagree, I said something like “cool, OK, I’ll do that” and changed the subject by saying hi to his young son. I so dreaded the awkwardness that disagreeing with him would cause that I lied to avoid it. Less than an hour later, a woman from his organization came to my door and asked if she could count on my support. I politely told her that I disagree with the measure and to have a good rest of her day, to which she replied condescendingly, “you disagree with making our schools safer?” Lol. At that point someone else came to the door and I let that person talk to her. This is a gated community where homeowners pay dues to keep solicitors out—I suspect my friend used his connections to the HOA to get permission for the organization to campaign here. If so, not cool. Anyway, how spineless was I to imply that I would support my childhood friend’s cause? What would you say instead? “I don’t believe in public education, but since it will probably pass I hope the kids benefit from it?” Ugh better but still so cringeworthy. I want to be able to disagree respectfully and shut it down without burning a friend. You can tell I don’t have much experience in these situations. I’ve always lived by a strict “no politics” policy in social situations unless I know I’m talking to someone who agrees with me.
  12. Cold-blooded murderers, every last one of them. https://www.google.com/amp/amp.washingtontimes.com/news/2018/mar/13/house-democrats-block-patients-right-try-bill/
  13. There is a very grassroots group that advocates for the cause and is a mix of good and bad. The leadership doesn’t have much of a grasp of how to argue, puts out poorly edited articles and social media content, and sometimes lives up to the other side's characterizion of patients as being easily misled. They blew me away last year by spearheading the Texas law that passed, which will be a game-changer if federal authorities don't interfere, so I have to give them some credit.
  14. As Nicky noted, the proprietary Regenexx procedure is approved in the Cayman Islands, where the regulations are less stringent than in the US (I had 20+ joints treated at the Cayman clinic last year with good results). Cultured stem cell treatments in general aren’t freely practicable anywhere to my knowledge, but are still performed in certain places throughout the world either through specials favors from local governments or where their legal status is uncertain. Japan also recently passed a law that significantly deregulates stem cell “drugs,” allowing them to skip phase-3 clinical trials (the most burdensome part of the approval process).
  15. Statutorily, a preparation of cells qualifies as “drug” subject to FDA regulation if the cells are “more than minimally manipulated.” The specific treatment I need calls for a patient's stem cells to be isolated from his bone marrow and culture-expanded to grow them to multiplicity. The expanded cells are then implanted into an arthritic joint, where, if the process is performed by skilled hands, they are well-documented to be capable of exerting reparative effects. In 2010, the FDA sued the company that pioneered this procedure on the grounds that the expanded cells are "more than minimally manipulated" (see ARI's commentary). The FDA prevailed, and it is now illegal for any doctor to administer culture-expanded stem cells in the US without obtaining a biologics license, the cost of which is so burdensome that it renders the procedure economically unviable in today’s regulatory environment. The cause also seems obstructed by parties with serious conflicts of interest. The former FDA commissioner said this: “When I was commissioner of the Food and Drug Administration (FDA) from 2005 to 2009, I saw firsthand how regenerative medicine offered a cure for kidney and heart failure and other chronic conditions like diabetes. Researchers used stem cells to grow cells and tissues to replace failing organs, eliminating the need for expensive supportive treatments like dialysis and organ transplants… For example, in August 2010, the FDA filed suit against a company called Regenerative Sciences. Three years earlier, the company had begun marketing a process it called Regenexx to repair damaged joints by injecting them with a patient’s own stem cells. The FDA alleged that the cells the firm used had been manipulated to the point that they should be regulated as drugs. A resulting court injunction halting use of the technique has cast a pall over the future of regenerative medicine.“ I don’t think it’s unreasonable to project that, by the end of the ensuing decade, the FDA vs. Regenerative Sciences decision will probably have resulted in millions of preventable deaths.
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